Drug Intermediates

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O/P-toluene sulfonamide is primarily used as a plasticizer due to its ability to improve stability, flexibility, salt resistance, and flow properties in resins. In particular, O/P-Toluene Sulfonamide is known for its ability to create a smooth and uniform gloss in resins.

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Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
Etoricoxib is a member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a sulfone, a member of bipyridines and an organochlorine compound.
Etoricoxib is a selective COX-2 inhibitor from Merck & Co. Currently it is approved in more than 80 countries worldwide but not in the US, where the Food and Drug Administration has required additional safety and efficacy data for etoricoxib before it will issue approval.
Molar mass: 358.842 g/molElimination half-life: 22 hoursFormula: C₁₈H₁₅ClN₂O₂SMetabolism: Hepatic, CYP extensively involved (mainly CYP3A4)ATC code: M01AH05 (WHO)